Counting on natural products for drug design.

TitleCounting on natural products for drug design.
Publication TypeJournal Article
Year of Publication2016
AuthorsT Rodrigues, D Reker, P Schneider, and G Schneider
JournalNature Chemistry
Volume8
Start Page531
Issue6
Pagination531 - 541
Date Published06/2016
Abstract

Natural products and their molecular frameworks have a long tradition as valuable starting points for medicinal chemistry and drug discovery. Recently, there has been a revitalization of interest in the inclusion of these chemotypes in compound collections for screening and achieving selective target modulation. Here we discuss natural-product-inspired drug discovery with a focus on recent advances in the design of synthetically tractable small molecules that mimic nature's chemistry. We highlight the potential of innovative computational tools in processing structurally complex natural products to predict their macromolecular targets and attempt to forecast the role that natural-product-derived fragments and fragment-like natural products will play in next-generation drug discovery.

DOI10.1038/nchem.2479
Short TitleNature Chemistry